T145
Sigma
4-Hydroxytolbutamide
≥98% (HPLC)
| Synonym: | N-(Butylaminocarbonyl)-4-hydroxymethylbenzenesulfonamide |
| CAS Number: | 5719-85-7 |
| Linear Formula: | C12H18N2O4S |
| Molecular Weight: | 286.35 |
| MDL number: | MFCD00144466 |
Description
| Other Notes | Metabolite of tolbutamide; formed by the cytochrome CYP2CIIC8 and IIC9 subfamily of P450 enzymes. |
Properties
| assay | ≥98% (HPLC) |
| solubility | ethanol: 12 mg/mL |
| 0.1 M NaOH: 4 mg/mL | |
| H2O: insoluble |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| WGK Germany | 3 |
Related Products
| Replaced by | UC160, 4-Hydroxytolbutamide |
References
| reference | Ho, et. al., Determination of tolbutamide hydroxylation in rat liver microsomes by high-performance liquid chromatography: Effect of psychoactive drugs on in vitro activity. Life Sci. 52, 21, (1993) |
| Parent, et. al., Effect of inflammation on the rabbit hepatic cytochrome P-450 isoenzymes: Alterations in the kinetics and dynamics of tolbutamide. J. Pharmacol. Exp. Ther. 261, 780, (1992) | |
| Relling, et. al., Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily. J. Pharmacol. Exp. Ther. 252, 442, (1990) |
